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Thinking Your Way Through.....
The Quarantine Quandary
By
Sharla Ishmael
How do you know the cattle you just purchased won’t bring along an infectious hitchhiker, like BVD or Johne’s? Using quarantine areas is one way, in some situations, to mitigate that risk. The trick is knowing when and how.

When a new cow is added to the herd, there might be a little scuffling until the order of social dominance is reestablished. But one thing her pasture-mates shouldn’t have to fight is exposure to harmful pathogens the new gal could be shedding in her urine, feces or nasal secretions, though she doesn’t look one bit sick.

Quarantining her for a period for time may be one way to protect your herd against any disease that might be secretly incubating inside her. But it’s not always the right thing to do. Whether or not to isolate any newly purchased animals depends on the age or class of animal, ranch or area of origin, diseases that are probable, the balance between cost of treatment vs. cost of prevention and other factors.

There is no simple answer for every situation, which is one reason that many producers don’t get it right, according to experts in biosecurity.

Dr. Michael Sanderson, DVM, of Kansas State University is one of several folks who helped put together a great resource on all facets of biosecurity for producers on the web at www.farmandranchbiosecurity.com. The website is a cooperative effort between the University of Nebraska, Iowa State University and Kansas State University.

“One of the things that I’ve seen in talking to producers, and in the survey work that we’ve done, is that producers don’t seem to understand when they ought to quarantine and how long it has to be,” he explains. “Veterinarians don’t always understand it either. Sometimes, they’re doing stuff that isn’t going to accomplish their goals.

“For example, in the NAHMS (National Animal Health Monitoring System) BEEF 97 survey, producers weren’t testing for brucellosis. They were more likely to quarantine them, and quarantine isn’t an effective method for controlling this risk of introducing brucellosis to the herd unless you’re also testing. The cows don’t look like there’s anything wrong with them and in 30 days of quarantine, you’re not going to see any clinical signs.”

Sanderson encourages producers to sit down with their veterinarian, go through their individual risk factors and better understand what diseases their cattle may be susceptible to, how these diseases are transmitted, how long the pathogens that cause them survive in the environment and how long cattle are preclinical.

“It’s a complex enough of an issue that you can’t just make a set of rules that this is what everybody should do,” he says. “It depends on the individual ranch.”

However, with that proviso in mind, there are some general guidelines that can help guide your thought process in working out the complexities of quarantine use in your own operation. And while it may seem like a hassle now, don’t underestimate how costly some of these diseases can be.

Several studies about the cost of disease are cited on the website. For example, “Losses from trichomoniasis (trich) and campylbacteriosis (vibrio) have reduced calving rates by 30 percent to 50 percent before detection and have resulted in average losses over $150 per beef cow unit.” Ouch!

When Quarantine is Useful
“The philosophy behind quarantine is based on if cattle come in and they appear to be healthy, but they are infected, they’re just not showing any clinical symptoms, then they are going through an incubation period,” explains Dr. Buddy Faries, DVM, of Texas A&M University. “All infectious agents that enter cattle’s bodies, no matter what route – by horsefly bite or needle or inhaled or ingested – those germs don’t show any symptoms immediately whether they are viruses or bacteria.
“There is a period of time that they have to invade the tissues and multiply before they reach a certain stage where they can produce a disease,” he says. “That length of incubation period is all over the board, depending in the disease agent. If it’s a respiratory virus, that may exhibit itself as a clinical sign in just a few days or a week.

“But many of the bacterial diseases like leptospirosis, it may be 30 or 40 days before they’re showing clinical signs. Another thing is if they’re going to break with a disease, they break in that quarantine area and the only cattle exposed are the others in that confined area.”

So, if the disease you’re concerned about has a short incubation, like IBR (Infectious Bovine Rhinotracheitis) in stocker calves, keeping them isolated for a short time might be appropriate from a health standpoint, (assuming they might otherwise have some type of contact with the breeding herd) though it may or may not make sense from an economic perspective.

However, if you’re wary about any of your new replacement heifers being persistently infected with BVD (Bovine Viral Diarrhea), quarantine would not be effective – at least not unless you tested those animals while they were isolated.

The same goes for new herd bulls in that combining testing with quarantine is the appropriate action. Unless they are virgin bulls, testing for venereal diseases like trich is extremely important, as is waiting for the test results before turning them out with the cows.

On the other hand, testing is not a simple cure-all either.

“BVD is one of those diseases where quarantine is valuable, because we have a good test that we can run during that time and know the outcome for that cow or calf before we introduce them to the resident herd,” explains Sanderson. “That said, it also matters what class of cattle you’re talking about whether it’s justified to test them.”

The accuracy of the test for each disease is something you certainly need to discuss with your vet.
On his web presentation,Sanderson says, “We do have a test for trichamoniasis. It works best on bulls; it actually works less well on cows. But the sensitivity is about 70 percent. So, if you lined up 100 positive bulls and cultured them all, you’d get 30 false negatives. So on a one-time run through, trich testing is not ideal.”

A word about vaccinations, This vet says they do their job, some more so than others, but they can also be easily overwhelmed.

“Producers generally look at vaccinations as sort of the magic bullet. ‘If we just vaccinate, things will go away.’ And in reality, that’s not the case,” says Sanderson. He uses the trich vaccine as an example. “That data would suggest that it does blunt the effect of an outbreak…. But it will not stop or prevent an outbreak.”

The next question is, if the disease you’re trying to evade does merit the use of a quarantine period, whether you test or not, how long should you keep the new animal(s) apart from the herd?

A Matter of Time
Faries says there is a lack of clinical studies to determine proper quarantine times for each infectious disease, but he can give you a range based on experience and practicality.
“It’s been recommended (to quarantine new purchases) anywhere from two weeks to two months,” he explains. “The longer they stay quarantined, maybe the safer the producer is to determine if there’s a problem or not. But two weeks could be ideal for a particular set of cattle coming in. If I buy some cattle from you private treaty and I know your place, I may feel comfortable with one or two weeks.

“But if I buy mixed cattle from sale barns and order buyers, there’s probably going to be some transmission going on,” Faries says. “If the cattle are coming in from some country where there’s some lepto exposure, I probably need to hold them 30 or 40 days. Then you get some longstanding bacteria, like anaplasmosis, where the incubation period could be up to 60 days. However, the mechanics of holding cattle for two months gets to be extreme.”

For his part, Sanderson says, “If you’re going to use quarantine alone, it probably needs to be 30 days to make sure whatever disease they might have, they’re going to get over it before you introduce them to the resident herd. Thirty days is a nice round number, some people use 21 days, and in most cases that’s probably okay.

“For diseases like Johne’s, salmonella and lepto, where we may not see clinical signs, there’s no length of quarantine – except permanent – that would prevent the rest of the herd from being exposed.”

That brings us to the question of where to locate your quarantine areas if you need them.

Location, Location, Location
Drainage is a big concern to Sanderson. “With lepto, for example, it’s not just a matter of nose-to-nose or aerosol contact, but also drainage. It lives in stagnant water. If your quarantine pen drains into your calving pen, that’s a bad thing. If we can avoid standing water, lepto isn’t going to survive very long. Good drainage is a wonderful thing. You need to think for each particular disease, what are the issues, where do we need to stop transmission, how is it transmitted?”

Along with paying attention to drainage, fenceline contact is another factor to consider when assigning pens or pastures. It doesn’t do much good to quarantine if the isolated animals can rub noses with vulnerable neighbors.

Of course you can do all the right things to prevent diseases from being spread but there are things you can’t exert much control over, like the neighbor’s dog coming over and leaving behind some neospora or the other neighbor’s bull jumping the fence and sharing something nasty.
Then there is the environment that cow-calf operations exist in where you have wide open spaces for the most part, and your cattle aren’t the only inhabitants. Wildlife on your place can also be a disease reservoir for things like lepto, neospora, salmonella, coccidiosis, etc.

Even flies and other biting insects can spread disease. So fly control and other wildlife population management tools can compliment your other biosecurity measures. Also, some of these diseases (e. coli, salmonella, brucellosis, etc.) can also affect your employees and family members if you’re not careful. Even using banked colostrum, especially from dairies, carries a risk of disease with it.

Keeping the Area Clean
If you’re using quarantine areas, another factor to consider is what needs to be done if any of the isolated animals do break with a disease. Once the animal is removed from the area, are there contamination issues to deal with before a new set of cattle occupies the pen or pasture?
Some pathogens can live in the ground or water or even on squeeze chutes and other equipment for a period of time, some longer than others. So, these experts say you need to have a rotation schedule for your quarantine areas to give those pathogens time to die out.

“We might disinfect some equipment, chutes, dehorners nose tongs, that type of thing,” says Faries. “But if the environment is contaminated, there’s not much you can do with it. We don’t have anything chemical-wise that we could spread as a disinfectant. The normal recommendation is to rest that area for 30 days, though any day rested is a benefit compared to an animal handling facility that is used every day.

“Hopefully, we would have some dry weather and lots of sun,” he adds. “If that area is grassy, they can mow it and have more exposure to sunlight. If we had sick cattle in there, the topsoil can be removed with a blade and then replace the topsoil. Especially with a hospital holding area, the area should be built so that you can get in there with a tractor and blade between cattle.”
In terms of diseases that can cause an environmental contamination problem, this list would include Johne’s, leptospirosis and the gastrointestinal bugs like salmonella, e. Coli and coccidiosis, plus the clostridium group.

“Type B and C clostridium hit in calves under 30 days of age; type D can be any age,” explains Faries. “Here is a group with clostridium in your pen and those formed spores go in the ground. Now you bring in other cattle and they swallow these blackleg-type spores and instead of causing blackleg they cause blackgut.

“If one of them died of blackleg in the pen, you could get further contamination from dragging him around and spreading discharge or the buzzards opening him up or just decomposing. Any of those clostridium would contaminate the soil,” he says.

“But you’ve got other diarrhea caused by viruses, like rotavirus or coronavirus, and those don’t live very long in the environment. However if the holding area becomes contaminated, from germs in the urine or feces, and other cattle follow right after the sick ones, the viruses may live long enough that the next group is exposed.

“It’s a good matter of practice to rotate and rest your quarantine area whether animals got sick in it or not,” says Faries. “Also, it’s a mistake to go into your quarantine area and then your other pens or traps without disinfecting your clothing and boots. You could carry something out of there. You might even want to disinfect your trailer between loads, too.”

Analyzing the Costs
Of course, just to make things even more complicated, what makes sense from strictly a health standpoint may not necessarily add up on the financial side. Dr. John Lawrence, associate professor in agricultural economics at Iowa State University, has an excellent presentation of the economics of disease at www.farmandranchbiosecurity.com .

For example, he discusses the concept of marginal analysis for disease prevention:
“What is the value of an additional intervention versus its cost? The optimal is when the last dollar of prevention just pays for itself…. The trouble is where do you draw the line? If I get a benefit to cost ratio of 20, where every dollar I spend on cost I get $20 back, sure I’m going to do it. What about 10 or 5 or 1?”

In addition to the cost of disease, there is also the cost of biosecurity to consider, which may include not only investments in equipment or space but also the cost of management – setting up protocol and following it – and the cost of limiting your choices from a supplier standpoint.

“If you say you’re only going to buy bulls from a herd that has been Johne’s tested and guaranteed free, you may have only a handful of herds to pick from. What are you giving up in genetic progress because of that tradeoff?” Lawrence asks.

“We really deal in an issue of tradeoffs. It’s not an all or nothing type game. Cases like FMD, maybe zero tolerance at any cost is the approach we want to take. But for a lot of other diseases, zero tolerance may be very costly to achieve,” he points out.

So, balancing the cost of preventing a disease against the cost of treating the disease if you get it is one way to think about it. Such as, is the cost of quarantining those new cows more or less than the cost of treating some of the herd if they get exposed to a respiratory disease? Or BVD? Obviously, those two situations would have very different answers.

“If (preventing the disease) is highly costly and the treatment is extremely effective, we’re going to treat,” says Lawrence. “But if it’s highly costly and the treatment is not very effective, that’s one you might want to think about preventing in the first place. Or if the cost (of the disease) is low enough, you simply live with it.

“What are the variables? It’s the exercise of how you think through it,” he adds.

Sanderson says we don’t always know what the most cost-effective program is, but emphasizes you can’t spend more on the biosecurity program, including quarantine areas, than you save by having it in the first place.

“We need to decide what the real risks are,” he says. “We need better data in some areas to know what the real risks are, so that we can target our biosecurity efforts and dollars in the right area.”

Editor’s note: By the end of summer, check out the Kansas State University College of Veterinary Medicine website at www.vet.ksu.edu for a risk analysis tool that will help producers assess their risk of BVD and the most cost-effective option to control that risk. When this program is up, it will be the culmination of two years research by one of Sanderson’s grad students.

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